Cellular Basis for Therapeutic Choices in Heart Failure
نویسندگان
چکیده
منابع مشابه
Cellular basis for therapeutic choices in heart failure.
Acrucial experimental study in 1985 showed that the angiotensin-converting enzyme inhibitor (ACEi) captopril did more than reduce the afterand preload on the heart in failure; captopril also improved remodeling by lessening the degree of left ventricular (LV) dilation.1 A series of powerful clinical studies starting in 1987 established the crucial role of ACE inhibition in severe heart failure ...
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The pathogenesis of cardiomyopathy and heart failure (HF) is underpinned by complex changes at subcellular, cellular and extracellular levels in the ventricular myocardium. For all of the gains that conventional treatments for HF have brought to mortality and morbidity, they do not adequately address the loss of cardiomyocyte numbers in the remodeling ventricle. Originally conceived to address ...
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From the *Heart Pittsburgh Schoo Cardiomyopathy C California; zCente School of Medici University, Atlanta Siemens; has receiv purposes; and has r The Pittsburgh F GlaxoSmithKline, Relypsa, Scios, St. as the Eliot Cord Ahmanson Found ew therapeutic targets, agents, and strategies are needed to prevent and treat heart failure (HF) after a decade of failed research efforts to improve long-term pat...
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Clyde W. Yancy and James B. Young, eds 256 pages. Oxford, UK: Clinical Publishing; 2008. $77.00. ISBN 1–904392–40–7 The sobering statistics on heart failure in the United States are often repeated: the incidence approaches 10 per 1000 population after 65 years of age; the lifetime risk for both men and women over age 40 is 1 in 5; 1.1 million hospital discharges occur per year, with estimated c...
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Abnormal respiratory muscle function is thought to contribute to breathlessness and exercise intolerance in heart failure but little is known about possible alterations in the function of such muscle. We have measured tetanic force and intracellular Ca(2+) concentration ([Ca(2+)](i)) in isolated, arterially perfused hemidiaphragm preparations from a rabbit coronary artery ligation model of hear...
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ژورنال
عنوان ژورنال: Circulation
سال: 2004
ISSN: 0009-7322,1524-4539
DOI: 10.1161/01.cir.0000146803.14063.f7